Spying with James Bond in 007 First Light could challenge lower-end machines. Newly released recommended system requirements list a high amount of RAM for 1080p/60fps gameplay. A memory shortage resulting in higher costs have made upgrading PC specs a frightening prospect.
Those are not valid configs for AM4/5. You cannot mix IC in them to work right and you would have 3 ranks per channel on DDR4 so it would not work correctly as you need one or a power of 2. You could technically get single rank ram sticks from micron that are 12GB, but the cost is more than 16GB sticks so I would go back to not a valid option. You could run one 24GB stick as well, but you should not be recommending that.
You could run less than one command per clock and make it work with mixed configs, but it is just a bad idea and not recommended or in spec.
If you had socked 1366 or one of the HEDT quad channel set ups running with one stick since a stick or slot died, then sure it would be a valid config.