Frankly, it seems somewhat self-evident based on the fact that Valve chose a Hawk Point 2 CPU (last gen laptop CPU with 2 big and 4 little cores) with a last gen laptop RX7600M GPU on a desktop, and also the fact that Valve calls them “semi-custom.”

But here’s the analysis: https://youtu.be/sJI3qTb2ze8

Depends on how you loosely you feel about “why”. Was battery life a consideration? Sure. But it wasn’t really the primary consideration. Valve’s current track record is that they are masters at making a product that’s surprisingly workable out of scrapyard parts that they got for cheap.

Valve didn’t design the Steam Deck’s chip - AMD designed it for Microsoft initially before the deal fell through. Then AMD offered the chips to Valve for cheap to recoup the costs.

Likewise, Valve didn’t intentionally choose the parts in the upcoming Steam Machine. Valve just bought AMD’s excess stock. That’s why the Steam Machine uses such an unusual and unbalanced CPU/GPU combo.

I honestly think SD2 is going to use x86, not for any particular reason, but because AMD is most likely going to have excess stock that’s x86 at the time that Valve designs it

It depends on which part of your eye is nonfunctional. It turns out there’s multiple redundancies for sensing light, so you could be blind but still be submitting signals to your circadian clock. If your eyes are completely nonfunctional, then yeah you’d have a pretty screwed up clock.

Young-ish introvert guy here. It’s definitely getting harder and harder over time. IMO the big problem is that nowadays, people don’t need to learn to communicate. And so many people never learn. There’s too many interesting things to do while you lock yourself away in your house. In the past, even introverts had to learn to communicate. What else were they going to do? Sit and stare at the wall?

What’s the solution? Well, you have to be more deliberate with your time and effort. You need to learn to communicate, so learn to communicate. My rule of thumb is that, on average, you need to spend at least half of your waking day outside. Whether for work, or hobby, or shopping, etc. - being outside for any reason is infinitely more useful for socializing than staying indoors.

Also, don’t stagnate. It’s very easy to get comfortable with what you’ve been doing and to keep doing what you’ve been doing. Again, be deliberate about how you choose to spend your time. Pick up new skills. Learn new hobbies. Try out new restaurants. Explore a bit. The more you learn, the better you get at learning. Become well-rounded, knowledgeable, cultured.

Nine sols. A metroidvania with parry-based combat and insanely good plot.

My understanding is that there was a scene where a young girl rides a naked man/woman around. Apparently it has since been changed to make the child older, but… I can perfectly understand why anyone would be hesitant to accept such a game based on that description alone. Even if it’s not intended to be sexual, the developers were certainly pushing the line

I think it really depends on your definition of what counts as year of Linux. Will Linux usage ever beat Windows or Mac? Of course not. But it can definitely get popular enough that companies have to think really hard about whether they need to support Linux or not. And meanwhile, Linux isn’t going to get popular overnight (or in a year, for that matter). So do you consider the year of the Linux to be the end of growth? Middle of growth? Or beginning of growth?

For me, I think year of the Linux desktop already passed in 2021, with the launch of the steam deck (where I’m defining year of Linux to be the point where Linux usage picks up and will hopefully end at a point where companies have to take Linux seriously)

Thanks, we had that issue but I think we just solved it by downclocking

That makes sense, but unfortunately in a frustratingly unhelpful way. NF-kB is the central mediator of cellular immunity. What that means is that everything that needs an immune response triggers NF-kB and everything immunity-related gets activated due to NF-kB. Likewise, TNFa is the prototypical pro-inflammatory cytokine. It’s remarkably good at triggering immune responses in a wide variety of cells, and every immune response that I know involves TNFa in some way.

In other words, having inflammatory symptoms be caused by NF-kB>TNFa is less of a “that’s an interesting pathway” and more of a “yeah, of course NF-kB and TNFa would be involved, what’s new?”

The concern is that we don’t really know what’s activating NF-kB in the first place, and so as a result you can’t really fix the core problem. And because NF-kB and TNFa are involved in basically every immune process, it’s hard to tell if these proteins are the ones actually responsible for causing your symptoms. You’d be operating on a hunch, essentially. Though I will say that your unusually nondescript and broad symptoms do seem roughly in line with what I would expect from TNFa signaling.

All that to say, I’m not a doctor and I have no experience with translating knowledge into practicable therapies, so definitely talk to a doctor about it. But TNFa is very easy to detect in your blood, and if TNFa is causing your symptoms, then it’s really easy to just check to see if you’ve got high TNFa in your blood when you’re taking the antibiotics vs. when you’re not. If you had the money, you could even buy a test kit yourself and get an answer in a single day, assuming you know how to use the kit

I’m not familiar with COVID, but it does sound to me like you’ve got long COVID. I’ve got no advice on that front - frankly, I don’t think anybody really knows what’s up with that. I get the impression that that’s why the advice that you’ve received so far are primarily focused on treating symptoms.

If your hypothesis is correct that your antibiotic is helping through its immunomodulatory effects, then it looks like it’s acting primarily through inhibiting cytokine production. Messing with cytokines will certainly affect your ability to fight off infections, since that’s how your body signals to immune cells that there’s something wrong. Of course, immunity is all about balance, and you don’t need to block cytokine signaling completely in order to decrease it to manageable levels… A brief search shows that there are inhibitors for TNFa, which based on your links seem to be what you’re leaning towards as the molecular mediator.

Have you considered bringing this up to your doctor? I’m not sure how feasible it would be to do a “trial run” with one of these inhibitors to see if it helps your symptoms. However, it may be simple enough to ask for a blood test to measure the amounts of different cytokines in your blood. My understanding (don’t trust me on this - I’m not a clinician) is that standard blood tests don’t typically measure cytokines, which is potentially why your blood tests so far haven’t been able to pick anything up out of the ordinary. That would at least help rule in/out any possible causes.

I will also point out an alternative hypothesis that might be worth considering - it could be that the antibiotic is depleting your microbiome, which would reduce the same cellular pathways that your antibiotic is said to inhibit due to your cells being in less contact with bacteria. Have you tried other antibiotics, and did they have a similar effect?

Immunologist here: what you’re describing seems vague. Inflammation is honestly just an umbrella term that generally refers to any time when the immune system is doing something (hence the seemingly conflicting advice). As a result, it’s not entirely clear to me what specifically you’re referring to.

Remember that no pathogen will just sit there and let themselves be destroyed. Many will actively exploit the immune system to cause disease, and in those cases, having a stronger immune response is actually bad for you. As well, I’m not sure what you mean by having higher “baseline inflammation,” because again, inflammation isn’t a singular thing

Scientists don’t wait for mice to get cancer, then cure the cancer. That would be inefficient. They just force the mouse to get cancer instead. And cures are tested based on how quickly the mice die to the cancer with or without the drug

I like making costumes! If anything, it’s a good way of making clothes that you would never make otherwise, and there isn’t anywhere near an expectation of quality. Making a costume yourself basically automatically ensures that people would be impressed, no matter how shitty the costume is.

Regarding perfectionism, it’s something that I’ve had to learn throughout my various forays into arts - there’s going to be mistakes. There’s always going to be mistakes. You can’t avoid it, no matter how skilled you are. The skilled artists know how to avoid drawing attention to their mistakes, and that generally means that they just let it happen without caring about it. But also, it’s just a costume, and as mentioned above, people will be impressed regardless of how shitty it is.

Regarding effort, it requires a lot of effort. Because you’re making unusual clothes, you need to spend a lot of time to design it and make sure it fits properly. I designed costumes this year for me and my partner, and in total that took maybe 2 months. It’s also more expensive than costumes you buy online. The raw material (cloth, thread) was maybe around 200 USD total, roughly 4-5x the cost of a regular costume you can buy online, or 2x the cost of a niche costume that you can buy online. It’s definitely not a good use of money and time, but it’s a good hobby project.

Regardless of if you buy a costume or if you make one, here’s the trick: don’t skimp out on the wig. Most people don’t wear a wig, and the people who do tend to use cheap wigs. Cheap wigs have a plastic-y texture and are difficult to style. I get wigs from Epic Cosplay, which have a lot of different colors to choose from and tend to look fairly realistic.

Also, wigs never come with hair already at the right length! Make sure to give the wig a haircut, it’ll look way better if you remember

Gives a strangely similar vibe to seeing the slide reels. Pretty cool!

This trick also works for a lot of other non-steam games - always good to keep this trick in your hat

Custom, but I understand the appeal of sticking with the default.

I think the issue with wallpapers is that there’s a very fine balance that it needs to strike: not too simple that it’s monotonous, but not too fancy that it’s distracting and hides icons. Too many wallpapers swing too significantly in either extreme that I simply don’t like the vast majority of wallpapers that I find.

Interestingly, KDE seems to strike this balance relatively consistently - they must be aware and are actively attempting to strike that balance. I don’t know how else to explain it.

This is a pretty nuanced problem, in my opinion. Here are my thoughts:

1. You’re definitely judging them
2. I don’t necessarily think it’s wrong to judge them, but it would have to be for different reasons than you state. I would judge them for being personally incompatible with the fundamental tenets of society (ie that you contribute to it and act as a good citizen)
3. You can’t change the mind of someone who isn’t open to change. One of the things you’ll need to accept is that most people are only willing to learn from their own mistakes, and a good portion of those aren’t even willing to learn from their own mistakes consistently. You will need to wait until they regret their decisions before change can even be possible. And even then be aware that there’s a solid chance that they’ll still keep doing whatever they’ve been doing
4. It’s good that you’re thinking about this, but on the other hand, it’s not your responsibility to ensure that your friends have good lives. Your responsibility is to yourself, and if you act as though you have responsibility over other people, you come off as nosy, pushy, bossy. Be careful that you don’t confuse advising someone with assuming responsibility over that person.

I liked Control but Alan Wake was a sludge. Its age really shows. That being said, it wasn’t necessarily bad enough that I couldn’t tank through the game, but if Control were in lower A tier, Alan Wake would be upper C tier

State, I think?

It seems the rules are different for me than for you. I brought my backpack with my laptop. I did work during breaks. Or used my phone. I just made sure all electronics were off when in the court room. And I’m pretty sure I brought my water bottle too. The one thing that the security did enforce was my pepper spray, which I had to remove and hide in a bush outside. I’m not sure if that helps at all.

One thing you can do is to leave your laptop/things in the car. You can leave the building during breaks and then just come back into the building before the session restarts. That was what most of the jury did during breaks during my time