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In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

    • chonglibloodsport@lemmy.worldEnglish
      211·
      3 days ago

      Wow yes. So many older and retired workers from the skilled trades could benefit from this.

      It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.

      • Damage@feddit.itEnglish
        61·
        2 days ago

        Arthritis is not limited to trade workers, anyone can have it.

        And it isn’t the only health issue physical work can cause.

    • roofuskit@lemmy.worldEnglish
      185·
      3 days ago

      Perfect for making you work the remainder of your life. No more arthritis? Great, now work until death to pay for it.

      • rumba@lemmy.zipEnglish
        6·
        2 days ago

        also cancer :)

        Any of the “regrows damage” side of thing scares the fuck out of me. I mean I want it to come and ASAP, but I also don’t want to play chicken with C

        • Lemmyoutofhere@lemmy.caEnglish
          12·
          2 days ago

          Cancer is largely based on your genetics, except for extreme causes like asbestos or smoking. It’s worth the risk.

          • rumba@lemmy.zipEnglish
            2·
            2 days ago

            Not in this case.

            “Stem cells survive much longer than ordinary cells, increasing the chance that they might accumulate genetic mutations. It might take only a few mutations for one cell to lose control over its self-renewal and growth and become the source of cancer.”

            https://www.hsci.harvard.edu/stem-cells-and-cancer

            • Lemmar@lemmy.todayOPEnglish
              1·
              2 days ago

              The news article, as well as the published work, state that:

              Cartilage regeneration appears to occur through gene expression changes in pre-existing chondrocytes, rather than stem or progenitor cell proliferation.

              Long-term side effects will need to researched of course and there might still be stem cells involved in the process, however that doesn’t seem to be the case according to what we know as of now.

              • rumba@lemmy.zipEnglish
                1·
                2 days ago

                I will gladly throw it on top of my monstrous pile of promising-looking research in hopes that it becomes a successful procedure.