• 8 Posts
  • 658 Comments
Joined 2 years ago
Cake day: August 19th, 2023
  • Caveman@lemmy.worldtoNo Stupid Questions@lemmy.world•Why does everyone here think they're autistic or ADHD? The memes all describe normal human foibles.
    2·
    3 days ago

    I was in denial about being autistic for around a decade after I first had suspicion because of exactly the reasoning you provide.

    To provide some insight to my experience is that I had to manually decode all the non-verbal communication with logic while keeping track of the verbal stuff and monitoring my own expression back when I was masking. That shit is exhausting. Masking isn’t just picking a personality to wear based on the occasion, it’s doing that while it doesn’t come naturally and consciously tweaking behavior. Jokes on us, we give of the uncanny valley vibes when do that because it “feels off”.

    If there’s something loud around me I will intensely try to hear what people say to me but I just can’t because the surrounding is louder.

    I was so bad at throwing and kicking balls that I was made fun of despite actually practicing both football and handball.

    I went to sleep scared for a long time because I imagined people breaking in because of slightest squeek in the house.

    It’s also hard to explain how easy it is to have conversations with other autistic people vs normies.

  • Caveman@lemmy.worldtoAsk Lemmy@lemmy.world•What did you stupidly believe as a child?
    7·
    4 days ago

    I mean, it’s kinda true. A rocket just makes fire which expands and pushes whatever it burns out to make it go fast. You got the fire, the fire pushes things away from whatever you’re burning and the rest is just optimisation.

    If you manage to make a helium balloon that floats in the air, attach a burning log fire to the bottom of it and enclose it in a way that the air intake is on the top and outlet is on the bottom you’ve made an engine that you just need to aim with a ballast weight.

    Still wrong, but you were onto something.

  • Caveman@lemmy.worldtoYou Should Know@lemmy.world•YSK that your gut is connected to your brain. Bacterias in your gut can naturally create serotonin and dopamine. If you have happy gut bacterias, you will feel happier
    3·
    5 days ago

    I feel like Wikipedia will be way better than explaining. I’ll put it here inside a spoiler tag. I don’t know a lot about this besides the basics so I won’t be able to do it justice. Fair to say it does a lot of stuff.

    https://en.wikipedia.org/wiki/Serotonin

    Biological role > Outside the nervous system.

    Digestive tract (emetic)

    Serotonin regulates gastrointestinal (GI) function. The gut is surrounded by enterochromaffin cells, which release serotonin in response to food in the lumen. This makes the gut contract around the food. Platelets in the veins draining the gut collect excess serotonin. There are often serotonin abnormalities in gastrointestinal disorders such as constipation and irritable bowel syndrome.[75]

    If irritants are present in the food, the enterochromaffin cells release more serotonin to make the gut move faster, i.e., to cause diarrhea, so the gut is emptied of the noxious substance. If serotonin is released in the blood faster than the platelets can absorb it, the level of free serotonin in the blood is increased. This activates 5-HT3 receptors in the chemoreceptor trigger zone that stimulate vomiting.[76] Thus, drugs and toxins stimulate serotonin release from enterochromaffin cells in the gut wall which can induce emesis. The enterochromaffin cells not only react to bad food but are also very sensitive to irradiation and cancer chemotherapy. Drugs that block 5HT3 are very effective in controlling the nausea and vomiting produced by cancer treatment, and are considered the gold standard for this purpose.[77]

    Lungs

    The lung,[78] including that of reptiles,[79] contains specialized epithelial cells that occur as solitary cells or as clusters called neuroepithelial bodies or bronchial Kulchitsky cells or alternatively K cells.[80] These are enterochromaffin cells that like those in the gut release serotonin.[80] Their function is probably vasoconstriction during hypoxia.[78]

    Skin

    Serotonin is also produced by Merkel cells which are part of the somatosensory system.[81]

    Bone metabolism

    In mice and humans, alterations in serotonin levels and signalling have been shown to regulate bone mass.[82][83][84][85] Mice that lack brain serotonin have osteopenia, while mice that lack gut serotonin have high bone density. In humans, increased blood serotonin levels have been shown to be a significant negative predictor of low bone density. Serotonin can also be synthesized, albeit at very low levels, in the bone cells. It mediates its actions on bone cells using three different receptors. Through 5-HT1B receptors, it negatively regulates bone mass, while it does so positively through 5-HT2B receptors and 5-HT2C receptors. There is very delicate balance between physiological role of gut serotonin and its pathology. Increase in the extracellular content of serotonin results in a complex relay of signals in the osteoblasts culminating in FoxO1/ Creb and ATF4 dependent transcriptional events.[86] Following the 2008 findings that gut serotonin regulates bone mass, the mechanistic investigations into what regulates serotonin synthesis from the gut in the regulation of bone mass have started. Piezo1 has been shown to sense RNA in the gut and relay this information through serotonin synthesis to the bone by acting as a sensor of single-stranded RNA (ssRNA) governing 5-HT production. Intestinal epithelium-specific deletion of mouse Piezo1 profoundly disturbed gut peristalsis, impeded experimental colitis, and suppressed serum 5-HT levels. Because of systemic 5-HT deficiency, conditional knockout of Piezo1 increased bone formation. Notably, fecal ssRNA was identified as a natural Piezo1 ligand, and ssRNA-stimulated 5-HT synthesis from the gut was evoked in a MyD88/TRIF-independent manner. Colonic infusion of RNase A suppressed gut motility and increased bone mass. These findings suggest gut ssRNA as a master determinant of systemic 5-HT levels, indicating the ssRNA-Piezo1 axis as a potential prophylactic target for treatment of bone and gut disorders. Studies in 2008, 2010 and 2019 have opened the potential for serotonin research to treat bone mass disorders.[87][88]

    Organ development

    Since serotonin signals resource availability it is not surprising that it affects organ development. Many human and animal studies have shown that nutrition in early life can influence, in adulthood, such things as body fatness, blood lipids, blood pressure, atherosclerosis, behavior, learning, and longevity.[89][90][91] Rodent experiment shows that neonatal exposure to SSRIs makes persistent changes in the serotonergic transmission of the brain resulting in behavioral changes,[92][93] which are reversed by treatment with antidepressants.[94] By treating normal and knockout mice lacking the serotonin transporter with fluoxetine scientists showed that normal emotional reactions in adulthood, like a short latency to escape foot shocks and inclination to explore new environments were dependent on active serotonin transporters during the neonatal period.[95][96]

    Human serotonin can also act as a growth factor directly. Liver damage increases cellular expression of 5-HT2A and 5-HT2B receptors, mediating liver compensatory regrowth (see Liver § Regeneration and transplantation)[97] Serotonin present in the blood then stimulates cellular growth to repair liver damage.[98]

    5-HT2B receptors also activate osteocytes, which build up bone[99] However, serotonin also inhibits osteoblasts, through 5-HT1B receptors.[100]

    Cardiovascular growth factor

    Main article: Cardiac fibrosis Serotonin, in addition, evokes endothelial nitric oxide synthase activation and stimulates, through a 5-HT1B receptor-mediated mechanism, the phosphorylation of p44/p42 mitogen-activated protein kinase activation in bovine aortic endothelial cell cultures.[clarification needed][101] In blood, serotonin is collected from plasma by platelets, which store it. It is thus active wherever platelets bind in damaged tissue, as a vasoconstrictor to stop bleeding, and also as a fibrocyte mitotic (growth factor), to aid healing.[102]

    Adipose tissue

    Serotonin also regulates white and brown adipose tissue function, and adipocytes are capable of producing 5-HT separately from the gut. Serotonin increases lipogenesis through HTR2A in white adipose tissue, and suppressed thermogenesis in brown adipose tissue via Htr3.[103]

  • Caveman@lemmy.worldtoYou Should Know@lemmy.world•YSK that your gut is connected to your brain. Bacterias in your gut can naturally create serotonin and dopamine. If you have happy gut bacterias, you will feel happier
    4·
    5 days ago

    That’s true, the gut and the brain are tightly linked and are in constant communication with each other, an obvious example is hunger for example.

    I felt the need to comment this because serotonin and dopamine produced in the gut have completely different functions from the dopamine and serotonin in the brain. On top of that the body keeps those completely separate with the blood brain barrier so it can regulate those different functions individually.

    The gut does play a part in tryptophan production and extraction which passes the blood brain barrier and the brain uses to make serotonin so the gut does affect serotonin levels. But that’s just “eat healthy, feel good” type of stuff.

    I’m just not a fan of oversimplified version of this where people say “90-95% of serotonin is made in the gut, serotonin is the feel good hormone so gut affects happiness”. I mean, most people are aware that what you eat affects your mood but saying the gut is responsible for producing the hormones for the brain is just wrong when talking about dopamine and serotonin.

  • Caveman@lemmy.worldtoAsk Lemmy@lemmy.world•What paid software is absolutely worth the money?
    8·
    7 days ago

    nzb360 that I got a perpetual license for at 10eur. It’s so easy and convenient to torrent stuff for my Jellyfin.

    Niagara launcher is free but I paid for the perpetual license. It’s a third party launcher that I really like.

    I’m also a Jetbrains fan depending on the language, they have so much support for everything just out of the box and are on Linux.

    Also games, but I guess people don’t want to hear those here. Factorio was definitely worth.

  • Caveman@lemmy.worldtoAsk Lemmy@lemmy.world•How do you deal with spending money for (unnecessary) luxuries?
    2·
    13 days ago

    I’m really bad at spending stuff on myself also. I like prioritising paying back loans, buying stock and so on since it pays itself back later on.

    The way I look at it is that the less I spend on luxuries the less I have to work (currently and in retirement) so I don’t feel weird about it.

    Another rule of thumb is to delay purchases by 3 months and it doesn’t set back your financial goals. If you’ve been wanting this Macbook now for 3 months and you have the money for it and you feel comfortable with your current financial situation I’d tell you to get it. If it’s an expensive car it’s a financial catastrophy usually so don’t get it even if you’ve wanted it for 3 months.

    No idea if that helps but don’t feel weird about being frugal. Frugality is incredibly useful and can set you up for an easy life.